Amyndas has generated next-generation proprietary Compstatins with very significant improvements (40.000-fold) in binding affinity to human C3, enhanced inhibitory potency, and extended circulating in vivo half-life of >50 hr in pre-clinical models (e.g. AMY-101, AMY-201; KD 0.05 nM) compared with a much shorter half-life for earlier analogues.
In addition, Amyndas has developed compounds to target complement inhibition on cell surfaces by Compsorbin, which was first described by Dr. Lambris in 2011 (Wu et al. J. Immunology 186 (2011) 4269-77). Compsorbin is a fourteen amino acid cyclic peptide that binds to complement factor H and inhibits biomaterial and cell induced complement activation.
Moreover, Amyndas has developed compounds to target complement inhibition using factor H mini constructs which are 10x more active than earlier target complement inhibition compounds. Patents have been issued and U.S. and PCT patents have been filed for compositions of matter and methods of use for modulators of the complement cascade, and for development of products for the treatment of diseases and disorders with a major inflammatory component.